Duke vs Siena: Game Preview & Best Bets (East Region, 2025-2026 NCAA Tournament)

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Duke vs Siena: Game Preview

Let's cut to the chase: Duke vs Siena is likely to be a blowout. Duke should cruise here as their length down low will be too much for Siena to handle, even if Patrick Ngongba sits out this game. Riley Mulvey has played fantastic defense down the stretch for the Saints, but he hasn't been going against anyone near the talent level of Cam Boozer.

We expect Siena to play drop coverage with Riley Mulvey down low, but that has resulted in them struggling heavily to defend the ball. That's where our best angle for this game comes from.

With Caleb Foster out, Cayden Boozer has taken the helm at the point and just carved up two solid drop coverages in the ACC tournament. He put up 16 points against both Clemson in the semifinals and Virginia in the finals, and I see him being able to do the same against the Saints. His current prop is only 9.5 points.

Meanwhile, Duke has been solid on defense all season. We do not see anything on the Siena side worth considering.

Duke vs Siena: Best Bets

• Cayden Boozer over 9.5 points (-125 on most books as of writing)

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